RT Journal Article
SR Electronic
T1 Clonality of anti-GM1 IgM antibodies in multifocal motor neuropathy and the Guillain-Barré syndrome
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 502
OP 504
DO 10.1136/jnnp-2014-308118
VO 86
IS 5
A1 Elisabeth A Cats
A1 W-Ludo van der Pol
A1 Anne P Tio-Gillen
A1 Frank P Diekstra
A1 Leonard H van den Berg
A1 Bart C Jacobs
YR 2015
UL http://jnnp.bmj.com/content/86/5/502.abstract
AB Objective Multifocal motor neuropathy (MMN) and the Guillain-Barré syndrome (GBS) are immune-mediated motor neuropathies with antibodies against the ganglioside GM1. In GBS, these antibodies are induced by molecular mimicry, but in MMN their origin is elusive. Methods We compared the light-chain use of anti-GM1 IgM antibodies in serum from 42 patients with MMN and 23 patients with GBS by ELISA. Results Exclusive use of either κ or λ light chains was found in 38 (90%) patients with MMN and 9 (39%) with GBS (p<0.001). Conclusions Anti-GM1 IgM antibodies in most patients with MMN are produced by only a single or very limited number of B-cell clones, whereas in most patients with GBS, anti-GM1 IgM antibodies are most likely polyclonal.