RT Journal Article
SR Electronic
T1 APOE genotype and neuroimaging markers of Alzheimer's disease: systematic review and meta-analysis
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 127
OP 134
DO 10.1136/jnnp-2014-307719
VO 86
IS 2
A1 Ying Liu
A1 Jin-Tai Yu
A1 Hui-Fu Wang
A1 Pei-Ran Han
A1 Chen-Chen Tan
A1 Chong Wang
A1 Xiang-Fei Meng
A1 Shannon L Risacher
A1 Andrew J Saykin
A1 Lan Tan
YR 2015
UL http://jnnp.bmj.com/content/86/2/127.abstract
AB Objective We aimed to examine the association of apolipoprotein E (APOE) ɛ4 genotype with neuroimaging markers of Alzheimer's disease: hippocampal volume, brain amyloid deposition and cerebral metabolism. Methods We performed a systematic review and meta-analysis of 14 cross-sectional studies identified in Pubmed from 1996 to 2014 (n=1628). The pooled standard mean difference (SMD) was used to estimate the association between APOE and hippocampal volume and amyloid deposition. Meta-analysis was performed using effect size signed differential mapping using coordinates extracted from clusters with statistically significant difference in cerebral metabolic rate for glucose between APOE ɛ4+ and ɛ4− groups. Results APOE ɛ4 carrier status was associated with atrophic hippocampal volume (pooled SMD: −0.47; 95% CI −0.82 to −0.13; p=0.007) and increased cerebral amyloid positron emission tomography tracer (pooled SMD: 0.62, 95% CI 0.27 to 0.98, p=0.0006). APOE ɛ4 was also associated with decreased cerebral metabolism, especially in right middle frontal gyrus. Conclusions APOE ɛ4 was associated with atrophic hippocampal volume in MRI markers, increased cerebral amyloid deposition and cerebral hypometabolism. Theses associations may indicate the potential role of the APOE gene in the pathophysiology of Alzheimer's disease.