TY - JOUR T1 - Deep grey matter involvement in multiple sclerosis: key player or bystander? JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 1293 LP - 1293 DO - 10.1136/jnnp-2014-308221 VL - 85 IS - 12 AU - Izumi Kawachi Y1 - 2014/12/01 UR - http://jnnp.bmj.com/content/85/12/1293.abstract N2 - Multiple sclerosis (MS) has been classically considered to be an autoimmune and inflammatory demyelinating disease that primarily affects the white matter (WM) in the central nervous system. However, because WM demyelination by itself cannot explain the full extent of clinical disabilities including cognitive impairments in patients with MS, renewed interest in grey matter (GM) pathology is now emerging.1–4GM lesions in MS are found in both cortical GM and deep GM by pathological and radiological studies. A 3D double inversion recovery technique on MRI enables a fivefold increase in the detection of cortical GM lesions, which are regarded as a better predictor of cognitive impairment than WM lesions in patients with MS. The cortical GM pathology is characterised as follows: … ER -