RT Journal Article
SR Electronic
T1 Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 126
OP 129
DO 10.1136/jnnp-2014-309690
VO 87
IS 2
A1 Giulio Disanto
A1 Rocco Adiutori
A1 Ruth Dobson
A1 Vittorio Martinelli
A1 Gloria Dalla Costa
A1 Tessel Runia
A1 Evgeniy Evdoshenko
A1 Eric Thouvenot
A1 Maria Trojano
A1 Niklas Norgren
A1 Charlotte Teunissen
A1 Ludwig Kappos
A1 Gavin Giovannoni
A1 Jens Kuhle
YR 2016
UL http://jnnp.bmj.com/content/87/2/126.abstract
AB Background Neurofilament light chain (NfL) represents a promising biomarker for axonal injury. We present the first exploratory study on serum NfL in patients with a clinically isolated syndrome (CIS) and healthy controls.Methods We investigated serum NfL levels in 100 patients with CIS with a short conversion interval to clinically definite multiple sclerosis (MS) (fast converters (FC), median (IQR) conversion time: 110 days (79–139)); 98 patients with non-converting CIS (non-converters (NC), follow-up: 6.5 years (5.3–7.9)); and 92 healthy controls.Results NfL levels were higher in FC (24.1 pg/mL (13.5–51.8)) and NC (19.3 pg/mL (13.6–35.2)) than in healthy controls (7.9 pg/mL (5.6–17.2)) (OR=5.85; 95% CI 2.63 to 13.02; p=1.5×10−5 and OR=7.03; 95% CI 2.85 to 17.34; p=2.3×10−5, respectively). When grouping FC and NC, increased serum NfL concentration was also associated with increasing numbers of T2 hyperintense MRI lesions (OR=2.36; 95% CI 1.21 to 4.59; p=0.011), gadolinium-enhancing lesions (OR=2.69; 95% CI 1.13 to 6.41; p=0.026) and higher disability scores (OR=2.54; 95% CI 1.21 to 5.31; p=0.013) at CIS diagnosis.Conclusions If replicated in future studies, serum NfL may represent a reliable and easily accessible biomarker of early axonal damage in CIS and MS.