RT Journal Article
SR Electronic
T1 Reduced survival in patients with ALS with upper airway obstructive events on non-invasive ventilation
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 1045
OP 1050
DO 10.1136/jnnp-2015-312606
VO 87
IS 10
A1 Marjolaine Georges
A1 Valérie Attali
A1 Jean Louis Golmard
A1 Capucine Morélot-Panzini
A1 Lise Crevier-Buchman
A1 Jean-Marc Collet
A1 Anne Tintignac
A1 Elise Morawiec
A1 Valery Trosini-Desert
A1 François Salachas
A1 Thomas Similowski
A1 Jesus Gonzalez-Bermejo
YR 2016
UL http://jnnp.bmj.com/content/87/10/1045.abstract
AB Introduction Non-invasive ventilation (NIV) is part of standard care in amyotrophic lateral sclerosis (ALS). Intolerance or unavailability of NIV, as well as the quality of correction of nocturnal hypoventilation, has a direct impact on prognosis.Objectives We describe the importance of NIV failure due to upper airway obstructive events, the clinical characteristics, as well as their impact on the prognosis of ALS.Methods Retrospective analysis of the data of 190 patients with ALS and NIV in a single centre for the period 2011–2014. 179 patients tolerating NIV for more than 4 h per night without leaks were analysed.Results Among the 179 patients, after correction of leaks, 73 remained inadequately ventilated at night (defined as more than 5% of the night spent at <90% of SpO2), as a result of obstructive events in 67% of cases (n=48). Patients who remained inadequately ventilated after optimal adjustment of ventilator settings presented with shorter survival than adequately ventilated patients. Unexpectedly, patients with upper airway obstructive events without nocturnal desaturation and in whom no adjustment of treatment was therefore performed also presented with shorter survival. On initiation of NIV, no difference was demonstrated between patients with and without upper airway obstructive events. In all patients, upper airway obstruction was concomitant with reduction of ventilatory drive.Conclusions This study shows that upper airway obstruction during NIV occurs in patients with ALS and is associated with poorer prognosis. Such events should be identified as they can be corrected by adjusting ventilator settings.