RT Journal Article
SR Electronic
T1 D-MANNOSE TO PREVENT URINARY TRACT INFECTIONS IN MULTIPLE SCLEROSIS
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP e1
OP e1
DO 10.1136/jnnp-2016-315106.151
VO 87
IS 12
A1 Jalesh Panicker
A1 Véronique Phé
A1 Mahreen Pakzad
A1 Collette Haslam
A1 Gwen Gonzales
A1 Carmel Curtis
A1 Bernadette Porter
A1 Jeremy Chataway
YR 2016
UL http://jnnp.bmj.com/content/87/12/e1.59.abstract
AB Introduction Urinary tract infections (UTIs) are a significant problem in Multiple sclerosis (MS). D-mannose is a natural supplement shown recently to prevent UTIs, however benefits in multiple sclerosis (MS) are unknown.Objective To evaluate feasibility of using D-Mannose in MS patients reporting recurrent UTIs.Methods In this prospective single-centre, open-label study, participants were given D-mannose (Nature upplies Ltd, UK) 1.5 grams twice daily for 16-weeks and compliance recorded. Training was provided for recognising UTIs and self-monitoring using urine reagent-strip dipsticks. Results of dipsticks and cultures when UTIs were suspected, and antibiotic prescriptions, were recorded.Results Median compliance of 22 patients (18 females; median age 50 years (46–59), (group 1 not using catheters (n=10); group 2 catheter-users (n=12)) using D-Mannose was 100%; no adverse events were reported. In total, there were 61 episodes of suspected UTIs and 29 prescriptions for antibiotics. In group 1, median number of prescriptions was 1 (0–2.2) and culture-proven symptomatic UTIs 0.5 (0–1) and in group 2, 2 (0–3) prescriptions and 1 (0–2) culture-proven UTIs. Number of monthly UTIs significantly decreased in both groups (p<0.01).Conclusion The use of D-mannose in MS patients reporting recurrent UTIs is associated with a reduction in the number of UTIs and antibiotic prescriptions, without safety concerns. Larger studies are required to confirm efficacy.