RT Journal Article
SR Electronic
T1 SEIZURES AND CORTICAL LESIONS IN MOG IgG ASSOCIATED SYNDROMES
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP e1
OP e1
DO 10.1136/jnnp-2016-315106.135
VO 87
IS 12
A1 Shahd Hamid
A1 Mariyam Saviour
A1 Kerry Much
A1 Liene Elsone
A1 Maneesh Bhojak
A1 Anu Jacob
YR 2016
UL http://jnnp.bmj.com/content/87/12/e1.41.abstract
AB Background Antibodies to myelin oligodendrocyte glycoprotein (MOG) are being increasingly detected in patients with non-MS demyelination many of whom have the neuromyelitis optica spectrum disorders (NMOSD) phenotype. Cortical involvement or seizures are rare in AQP4 IgG NMO. Having encountered one MOG IgG+ve patient with seizures we systematically reviewed all our patients.Method Retrospective review of the clinical and MRI data of all MOG IgG +ve cases (n=28) and 100 patients with AQP4 IgG+ve NMOSD for seizures and cortical lesions.Results Only 1/100 NMOSD with AQP4 IgG had seizures (1%)-a 43-year old woman with epilepsy, her first seizure 5 years before the onset of NMOSD. Brain MRI was normal. 4/28 patients with MOG IgG had seizures (14%) that occurred along with an episode of demyelination. All 4 had cortical lesions and relapsing demyelination and are on immunosuppressants. 3 continue on antiepileptic drugs.Conclusion Patients with MOG IgG associated disease are more likely to have seizures (P<0.008, Fisher's test) and cortical MRI changes compared to AQP4IgG +ve cases. This may further support the view that the two are different diseases.