RT Journal Article SR Electronic T1 CHANGE IN VISUAL FUNCTION IN PARKINSON'S DISEASE JF Journal of Neurology, Neurosurgery & Psychiatry JO J Neurol Neurosurg Psychiatry FD BMJ Publishing Group Ltd SP e1 OP e1 DO 10.1136/jnnp-2016-315106.114 VO 87 IS 12 A1 Rimona S Weil A1 Katerina Pappa A1 Hannah Burn A1 Ivanna Pavisic A1 Sam Schwarzkopf A1 Jason Warren A1 Huw Morris YR 2016 UL http://jnnp.bmj.com/content/87/12/e1.18.abstract AB Aim To measure changes in visuo-perceptual processing in patients with Parkinson's disease without dementia.Methods Images of cats and dogs that had been skewed by varying amounts were shown to patients with idiopathic Parkinson's disease (defined by QSBB criteria) (n=16) and healthy controls (n=11). Mean disease duration was 4 years (Standard deviation 3 years). Average L-DOPA equivalent dose was 554 mg (SD 487 mg). On each trial, participants were asked to identify the presented animal to generate psychophysical curves of skew against correctness and determine the threshold for identifying the correct animal. Visual acuity, UPDRS-scores and neuropsychology performance was measured for each participant.Results Patients with Parkinson's disease, but without dementia, showed impaired ability to identify images that had been skewed, compared with healthy controls. The threshold for detection in patients was 61.2 degrees (SD 7.1 degrees), compared with 67.9 degrees (SD 2.1 degrees) in healthy participants, W=143, p=0.0056. The groups did not differ in visual acuity or neuropsychological performance.Conclusions We show subtle but definite impairment of complex visual processing in the initial phases of Parkinson's disease in patients without overt cognitive impairment. This work has important implications for understanding the diagnosis, biology and progression of Parkinson's disease.