TY - JOUR T1 - Prognostic significance of delayed intraventricular haemorrhage in the INTERACT studies JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 19 LP - 24 DO - 10.1136/jnnp-2015-311562 VL - 88 IS - 1 AU - Tom J Moullaali AU - Shoichiro Sato AU - Xia Wang AU - Alejandro A Rabinstein AU - Hisatomi Arima AU - Cheryl Carcel AU - Guofang Chen AU - Thompson Robinson AU - Emma Heeley AU - Edward Chan AU - Candice Delcourt AU - Christian Stapf AU - Charlotte Cordonnier AU - Richard I Lindley AU - John Chalmers AU - Craig S Anderson Y1 - 2017/01/01 UR - http://jnnp.bmj.com/content/88/1/19.abstract N2 - Background and purpose Intraventricular extension of intracerebral haemorrhage (ICH) predicts poor outcome, but the significance of delayed intraventricular haemorrhage (dIVH) is less well defined. We determined the prognostic significance of dIVH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trials (INTERACT 1 and 2).Methods Pooled analyses of the INTERACT CT substudies—international, multicentre, prospective, open, blinded end point, randomised controlled trials of patients with acute spontaneous ICH and elevated systolic blood pressure (SBP)—randomly assigned to intensive (<140 mm Hg) or guideline-based (<180 mm Hg) SBP management. Participants had blinded central analyses of baseline and 24 h CTs, with dIVH defined as new intraventricular haemorrhage (IVH) on the latter scan. Outcomes of death and major disability were defined by modified Rankin Scale scores at 90 days.Results There were 349 (27%) of 1310 patients with baseline IVH, and 107 (11%) of 961 initially IVH-free patients who developed dIVH. Significant associations of dIVH were prior warfarin anticoagulation, high (≥15) baseline National Institutes of Health Stroke Scale score, larger (≥15 mL) ICH volume, greater ICH growth and higher achieved SBP over 24 h. Compared with those who were IVH-free, dIVH had greater odds of 90-day death or major disability versus initial IVH (adjusted ORs 2.84 (95% CI 1.52 to 5.28) and 1.87 (1.36 to 2.56), respectively (p trend <0.0001)).Conclusions Although linked to factors determining greater ICH growth including poor SBP control, dIVH is independently associated with poor outcome in acute small to moderate-size ICH.Trial registration numbers NCT00226096 and NCT00716079. ER -