RT Journal Article
SR Electronic
T1 Venous imaging-based biomarkers in acute ischaemic stroke
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 62
OP 69
DO 10.1136/jnnp-2016-314814
VO 88
IS 1
A1 Munuera, Josep
A1 Blasco, Gerard
A1 Hernández-Pérez, María
A1 Daunis-i-Estadella, Pepus
A1 Dávalos, Antoni
A1 Liebeskind, David S
A1 Wintermark, Max
A1 Demchuk, Andrew
A1 Menon, Bijoy K
A1 Thomalla, Götz
A1 Nael, Kambiz
A1 Pedraza, Salvador
A1 Puig, Josep
YR 2017
UL http://jnnp.bmj.com/content/88/1/62.abstract
AB Vascular neuroimaging plays a decisive role in selecting the best therapy in patients with acute ischaemic stroke. However, compared with the arterial system, the role of veins has not been thoroughly studied. In this review, we present the major venous imaging-based biomarkers in ischaemic stroke. First, the presence of hypodense veins in the monophasic CT angiography ipsilateral to the arterial occlusion. Second, the asymmetry of venous drainage in the pathological cerebral hemisphere on CT and MRI dynamic angiography. Finally, the presence of hypodense veins on T2* -based MRI. From the physiological point of view, the venous imaging-based biomarkers would detect the alteration of brain perfusion (flow), as well as the optimisation of extraction oxygen mechanisms (misery perfusion). Several studies have correlated the venous imaging-based biomarkers with grade of collateral circulation, the ischaemic penumbra and clinical functional outcome. Although venous imaging-based biomarkers still have to be validated, growing evidence highlights a potential complementary role in the acute stroke clinical decision-making process.