PT  - JOURNAL ARTICLE
AU  - Izumi Kawachi
AU  - Hans Lassmann
TI  - Neurodegeneration in multiple sclerosis and neuromyelitis optica
AID  - 10.1136/jnnp-2016-313300
DP  - 2017 Feb 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 137--145
VI  - 88
IP  - 2
4099  - http://jnnp.bmj.com/content/88/2/137.short
4100  - http://jnnp.bmj.com/content/88/2/137.full
SO  - J Neurol Neurosurg Psychiatry2017 Feb 01; 88
AB  - Multiple sclerosis (MS) and neuromyelitis optica (NMO) are autoimmune demyelinating diseases of the central nervous system (CNS), having distinct immunological and pathological features. They have two pathogenic components, ‘inflammation’ and ‘neurodegeneration’, with different degrees of severity and pathogenetic mechanisms. The target antigen of autoimmunity in NMO is the water channel aquaporin-4 (AQP4), and antibodies directed against this antigen result in astrocyte damage. MS is a disease primarily affecting myelin and oligodendrocytes, but thus far, no MS-specific autoantigen has been identified. The distinct inflammatory processes in these diseases may trigger cascades of events leading to disease-specific neurodegeneration. Damage of the CNS tissue appears to be amplified by mechanisms that are in part shared by the two conditions and involve oxidative burst activation in microglia/macrophages, mitochondrial damage and axonal energy failure, Wallerian degeneration and meningeal inflammation. However, they appear to differ regarding the nature of the inflammatory response, the type and extent of cortical injury, and the type of astrocyte reaction and damage. Here, we provide a detailed comparison of the pathology between MS and NMO, which may help to define shared and disease-specific mechanisms of neurodegeneration in these diseases.