TY - JOUR T1 - Neuropsychiatric syndromes of multiple sclerosis JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 697 LP - 708 DO - 10.1136/jnnp-2016-315367 VL - 88 IS - 8 AU - Ruth Murphy AU - Stefani O’Donoghue AU - Timothy Counihan AU - Colm McDonald AU - Peter A Calabresi AU - Mohammed AS Ahmed AU - Adam Kaplin AU - Brian Hallahan Y1 - 2017/08/01 UR - http://jnnp.bmj.com/content/88/8/697.abstract N2 - Neuropsychiatric signs and symptoms occur frequently in individuals with multiple sclerosis (MS), either as the initial presenting complaint prior to a definitive neurological diagnosis or more commonly with disease progression. However, the pathogenesis of these comorbid conditions remains unclear and it remains difficult to accurately elucidate if neuropsychiatric symptoms or conditions are indicators of MS illness severity. Furthermore, both the disease process and the treatments of MS can adversely impact an individual’s mental health. In this review, we discuss the common neuropsychiatric syndromes that occur in MS and describe the clinical symptoms, aetiology, neuroimaging findings and management strategies for these conditions. ER -