TY - JOUR T1 - Pallidal deep brain stimulation for dystonia: a long term study JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 960 LP - 967 DO - 10.1136/jnnp-2016-315504 VL - 88 IS - 11 AU - Sara Meoni AU - Valérie Fraix AU - Anna Castrioto AU - Alim Louis Benabid AU - Eric Seigneuret AU - Laurent Vercueil AU - Pierre Pollak AU - Paul Krack AU - Eric Chevrier AU - Stephan Chabardes AU - Elena Moro Y1 - 2017/11/01 UR - http://jnnp.bmj.com/content/88/11/960.abstract N2 - Background Pallidal deep brain stimulation (globus pallidus internus (GPi) DBS) is the best therapeutic option for disabling isolated idiopathic (IID) and inherited (INH) dystonia. Acquired dystonia (AD) may also benefit from GPi DBS. Efficacy and safety in the long-term remained to be established.Objective To retrospectively assess long-term clinical outcomes and safety in dystonic patients who underwent GPi DBS.Methods Patients were videotaped and assessed preoperatively and postoperatively (1-year and at last available follow-up) using the Burke-Fahn-Marsden Dystonia Rating Scale (motor score (BFMDRS-M); disability score (BFMDRS-D)).Results Sixty-one patients were included (follow-up 7.9±5.9 years; range 1–20.7). In IID and INH (n=37), the BFMDRS-M improved at first (20.4±24.5; p<0.00001) and last (22.2±18.2; p<0.001) follow-ups compared with preoperatively (50.5±28.0). In AD (n=19), the BFMDRS-M ameliorated at 1-year (40.8±26.5; p<0.02) and late follow-ups (44.3±24.3; p<0.04) compared with preoperatively (52.8±24.2). In INH dystonia with other neurological features (n=4) there was no motor benefit. In IID and INH, the BFMDRS-D improved at 1-year (9.5±7.5; p<0.0002) and late follow-ups (10.4±7.8; p<0.016) compared with preoperatively (13.3±6.9). In AD, the BFMDRS-D reduced at 1-year (12.0±8.1; p<0.01) and late follow-ups (12.7 ±6.1; p=0.2) compared with preoperatively (14.35±5.7). Most adverse events were hardware related.Conclusions GPi DBS is an effective and safe treatment in most patients with dystonia. ER -