TY - JOUR T1 - Cerebellar lobule atrophy and disability in progressive MS JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 1065 LP - 1072 DO - 10.1136/jnnp-2017-316448 VL - 88 IS - 12 AU - Sirio Cocozza AU - Maria Petracca AU - Enricomaria Mormina AU - Korhan Buyukturkoglu AU - Kornelius Podranski AU - Monika M Heinig AU - Giuseppe Pontillo AU - Camilla Russo AU - Enrico Tedeschi AU - Cinzia Valeria Russo AU - Teresa Costabile AU - Roberta Lanzillo AU - Asaff Harel AU - Sylvia Klineova AU - Aaron Miller AU - Arturo Brunetti AU - Vincenzo Brescia Morra AU - Fred Lublin AU - Matilde Inglese Y1 - 2017/12/01 UR - http://jnnp.bmj.com/content/88/12/1065.abstract N2 - Objective To investigate global and lobular cerebellar volumetries in patients with progressive multiple sclerosis (MS), testing the contribution of cerebellar lobular atrophy to both motor and cognitive performances.Methods Eighty-two patients with progressive MS and 46 healthy controls (HC) were enrolled in this cross-sectional study. Clinical evaluation included motor and cognitive testing: Expanded Disability Status Scale, cerebellar Functional System score, Timed 25-Foot Walk Test, 9-Hole Peg Test (9-HPT), Symbol Digit Modalities Test (SDMT), Brief Visuospatial Memory Test–Revised (BVMT) and California Verbal Learning Test II (CVLT). Cerebellar volumes were automatically obtained using the Spatially Unbiased Infratentorial Toolbox. A hierarchical multiple linear regression analysis was performed to assess the relationship between MRI variables of supratentorial and cerebellar damage (grey matter fraction, T2 lesion volume, metrics of cerebellar atrophy and cerebellar lesion volume) and motor/cognitive scores.Results Patients with MS exhibited lower cerebellar volumes compared with HC. Regression analysis showed that cerebellar metrics accounted for extra variance in both motor and cognitive performances, with cerebellar lesion volume, cerebellar Lobules VI, Crus I and VIIIa atrophy being independent predictors of 9-HPT, SDMT, BVMT and CVLT performances.Conclusions Atrophy of specific cerebellar lobules explains different aspects of motor and cognitive disability in patients with progressive MS. Investigation of cerebellar involvement provides further insight into the pathophysiological basis of clinical disability in progressive MS. ER -