@article {Jim{\'e}nez-Balado651, author = {Joan Jim{\'e}nez-Balado and Iolanda Riba-Llena and Edurne Garde and Marta Valor and Belen Guti{\'e}rrez and Francesc Pujadas and Pilar Delgado}, title = {Prevalence of hippocampal enlarged perivascular spaces in a sample of patients with hypertension and their relation with vascular risk factors and cognitive function}, volume = {89}, number = {6}, pages = {651--656}, year = {2018}, doi = {10.1136/jnnp-2017-316724}, publisher = {BMJ Publishing Group Ltd}, abstract = {Objectives The clinical importance of hippocampal enlarged perivascular spaces (H-EPVS) remains uncertain. We aimed to study their association with vascular risk factors, cognitive function and mild cognitive impairment (MCI).Methods Data were obtained from the ISSYS (Investigating Silent Strokes in hYpertensives, a magnetic resonance imaging Study) cohort, which is a prospective study of patients with hypertension aged 50{\textendash}70 with no prior stroke or dementia. Participants were clinically evaluated and underwent a cognitive screening test, Dementia Rating Scale-2, which includes five cognitive subscales (attention, initiation/perseveration, conceptualisation, construction and memory). Besides, they were diagnosed with MCI or normal ageing following standard criteria. H-EPVS were manually counted on brain MRI according to a previous scale and defined as extensive when H-EPVS count was >=7 (upper quartile). Multivariate models were created to study the relationship between H-EPVS, vascular risk factors and cognitive function.Results 723 patients were included; the median age was 64 (59{\textendash}67) and 51\% were male. Seventy-two patients (10\%) were diagnosed with MCI and 612 (84.6\%) had at least 1 H-EPVS. Older age (OR per year=1.04, 95\% CI 1.01 to 1.08) and poor blood pressure treatment compliance (OR=1.50, 95\% CI 1.07 to 2.11) were independently associated with extensive H-EPVS. Regarding cognitive function, H-EPVS were independently and inversely correlated with verbal reasoning (β=-0.021, 95\% CI -0.038 to -0.003). No association was found between H-EPVS and MCI.Conclusions H-EPVS are a frequent finding in patients with hypertension and are associated with ageing and poor hypertension treatment compliance. Besides, H-EPVS are associated with worse verbal reasoning function.}, issn = {0022-3050}, URL = {https://jnnp.bmj.com/content/89/6/651}, eprint = {https://jnnp.bmj.com/content/89/6/651.full.pdf}, journal = {Journal of Neurology, Neurosurgery \& Psychiatry} }