PT  - JOURNAL ARTICLE
AU  - Lin Shi
AU  - Lei Zhao
AU  - Fu Ki Yeung
AU  - Shun Yiu Wong
AU  - Ronald K T Chan
AU  - Ming Fai Tse
AU  - Sze Chun Chan
AU  - Yee Ching Kwong
AU  - Ka Chun Li
AU  - Kai Liu
AU  - Jill M Abrigo
AU  - Alexander Y L Lau
AU  - Adrian Wong
AU  - Bonnie Y K Lam
AU  - Thomas W H Leung
AU  - Jianhui Fu
AU  - Winnie C W Chu
AU  - Vincent C T Mok
TI  - Mapping the contribution and strategic distribution patterns of neuroimaging features of small vessel disease in poststroke cognitive impairment
AID  - 10.1136/jnnp-2017-317817
DP  - 2018 Sep 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 918--926
VI  - 89
IP  - 9
4099  - http://jnnp.bmj.com/content/89/9/918.short
4100  - http://jnnp.bmj.com/content/89/9/918.full
SO  - J Neurol Neurosurg Psychiatry2018 Sep 01; 89
AB  - Objectives Individual neuroimaging features of small vessel disease (SVD) have been reported to influence poststroke cognition. This study aimed to investigate the joint contribution and strategic distribution patterns of multiple types of SVD imaging features in poststroke cognitive impairment.Methods We studied 145 first-ever ischaemic stroke patients with MRI and Montreal Cognitive Assessment (MoCA) examined at baseline. The local burdens of acute ischaemic lesion (AIL), white matter hyperintensity, lacune, enlarged perivascular space and cross-sectional atrophy were quantified and entered into support vector regression (SVR) models to associate with the global and domain scores of MoCA. The SVR models were optimised with feature selection through 10-fold cross-validations. The contribution of SVD features to MoCA scores was measured by the prediction accuracy in the corresponding SVR model after optimisation.Results The combination of the neuroimaging features of SVD contributed much more to the MoCA deficits on top of AILs compared with individual SVD features, and the cognitive impact of different individual SVD features was generally similar. As identified by the optimal SVR models, the important SVD-affected regions were mainly located in the basal ganglia and white matter around it, although the specific regions varied for MoCA and its domains.Conclusions Multiple types of SVD neuroimaging features jointly had a significant impact on global and domain cognitive functionings after stroke on top of AILs. The map of strategic cognitive-relevant regions of SVD features may help clinicians to understand their complementary impact on poststroke cognition.