TY - JOUR T1 - MOG antibody disorders and AQP4 antibody NMO spectrum disorders share a common immunopathogenesis JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 900 LP - 900 DO - 10.1136/jnnp-2018-318231 VL - 89 IS - 9 AU - Akiyuki Uzawa AU - Masahiro Mori AU - Satoshi Kuwabara Y1 - 2018/09/01 UR - http://jnnp.bmj.com/content/89/9/900.abstract N2 - Multiple sclerosis (MS) and neuromyelitis optica (NMO) are autoimmune inflammatory disorders of the central nervous system (CNS). The discovery of the disease-specific anti-aquaporin 4 (AQP4) autoantibody was a breakthrough in the pathogenesis of NMO.1 MS and NMO are distinct diseases with different immunological backgrounds and thereby cerebrospinal fluid (CSF) cytokine profiles.2 Briefly, Th17 and Th2-related cytokines are upregulated in NMO but not in MS. Among elevated CSF cytokines, interleukin (IL)-6 was the most remarkable, and its level was closely related to the levels of astrocytic damage marker (CSF glia fibrillar acidic protein (GFAP)) and recovery from attacks,2 3 suggesting that CSF IL-6 could contribute to the NMO … ER -