RT Journal Article
SR Electronic
T1 International multicentre validation of the arteriovenous malformation-related intracerebral haemorrhage (AVICH) score
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 1163
OP 1166
DO 10.1136/jnnp-2017-316259
VO 89
IS 11
A1 Marian C. Neidert
A1 Michael T. Lawton
A1 Louis J. Kim
A1 John D. Nerva
A1 Kaoru Kurisu
A1 Fusao Ikawa
A1 Juergen Konczalla
A1 Nazife Dinc
A1 Volker Seifert
A1 Julian Habdank-Kolaczkowski
A1 Taketo Hatano
A1 Makoto Hayase
A1 Dino Podlesek
A1 Gabriele Schackert
A1 Thomas Wanet
A1 Sven Gläsker
A1 Christoph J. Griessenauer
A1 Christopher S. Ogilvy
A1 Andreas Kneist
A1 Ulrich Sure
A1 Burkhardt Seifert
A1 Luca Regli
A1 Oliver Bozinov
A1 Jan-Karl Burkhardt
YR 2018
UL http://jnnp.bmj.com/content/89/11/1163.abstract
AB Objective The recently published arteriovenous malformation-related intracerebral haemorrhage (AVICH) score showed better outcome prediction for patients with arteriovenous malformation (AVM)-related intracerebral haemorrhage (ICH) than other AVM or ICH scores. Here we present the results of a multicentre, external validation of the AVICH score.Methods All participating centres (n=11) provided anonymous data on 325 patients to form the Spetzler-Martin (SM) grade, the supplemented SM (sSM) grade, the ICH score and the AVICH score. Modified Rankin score (mRS) at last follow-up (mean 25.6 months) was dichotomized into favourable (mRS 0-2, n=210) and unfavourable (mRS 3-6;n=115). Univariate and AUROC analyses were performed to validate the AVICH score.Results Except nidus structure and AVM size, all single parameters forming the SM, sSM, ICH and AVICH score and the scores itself were significantly different between both outcome groups in the univariate analysis. The AVICH score was confirmed to be the highest predictive outcome score with an AUROC of 0.765 compared with 0.705 for the ICH score and 0.682 for the sSM grade.Conclusion The multicentre-validated AVICH score predicts clinical outcome superior to pre-existing scores. We suggest the routine use of this score for future clinical outcome prediction and in clinical research.Trial registration number NCT02920645.