TY - JOUR T1 - Therapeutic non-invasive brain stimulation in amyotrophic lateral sclerosis: rationale, methods and experience JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 1131 LP - 1138 DO - 10.1136/jnnp-2018-320213 VL - 90 IS - 10 AU - Evan C Edmond AU - Charlotte J Stagg AU - Martin R Turner Y1 - 2019/10/01 UR - http://jnnp.bmj.com/content/90/10/1131.abstract N2 - The neurodegenerative syndrome amyotrophic lateral sclerosis (ALS) is characterised by increased cortical excitability, thought to reflect pathological changes in the balance of local excitatory and inhibitory neuronal influences. Non-invasive brain stimulation (NIBS) has been shown to modulate cortical activity, with some protocols showing effects that outlast the stimulation by months. NIBS has been suggested as a potential therapeutic approach for disorders associated with changes in cortical neurophysiology, including ALS. This article reviews NIBS methodology, rationale for its application to ALS and progress to date. ER -