RT Journal Article
SR Electronic
T1 Therapeutic non-invasive brain stimulation in amyotrophic lateral sclerosis: rationale, methods and experience
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 1131
OP 1138
DO 10.1136/jnnp-2018-320213
VO 90
IS 10
A1 Edmond, Evan C
A1 Stagg, Charlotte J
A1 Turner, Martin R
YR 2019
UL http://jnnp.bmj.com/content/90/10/1131.abstract
AB The neurodegenerative syndrome amyotrophic lateral sclerosis (ALS) is characterised by increased cortical excitability, thought to reflect pathological changes in the balance of local excitatory and inhibitory neuronal influences. Non-invasive brain stimulation (NIBS) has been shown to modulate cortical activity, with some protocols showing effects that outlast the stimulation by months. NIBS has been suggested as a potential therapeutic approach for disorders associated with changes in cortical neurophysiology, including ALS. This article reviews NIBS methodology, rationale for its application to ALS and progress to date.