TY - JOUR T1 - 200 AFFINITY: opicinumab in a targeted population of MS patients JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - e50 LP - e50 DO - 10.1136/jnnp-2019-ABN-2.169 VL - 90 IS - 12 AU - Bing Zhu AU - Peter A Calabresi AU - Gavin Giovanonni AU - Raj Kapoor AU - Robert Naismith AU - Hans-Peter Hartung AU - Douglas L Arnold AU - Paul Wolstencroft AU - Kristina Johnson Y1 - 2019/12/01 UR - http://jnnp.bmj.com/content/90/12/e50.3.abstract N2 - Introduction Opicinumab is a human monoclonal antibody against LINGO-1, a negative regulator of oligodendrocyte differentiation and axonal regeneration. The phase 2 SYNERGY study identified a patient subpopulation with a potentially enhanced response to opicinumab treatment.Methods AFFINITY (NCT03222973) is an ongoing, randomised, double-blind, placebo-controlled phase 2 study to evaluate the efficacy/safety of opicinumab vs placebo as an add-on to disease-modifying therapies in a targeted population. Inclusion criteria include: age 18–58; relapsing multiple sclerosis (MS) with ≤20-year duration; Expanded Disability Status Scale (EDSS) score 2.0–6.0; evidence of disease activity within 24 months prior to enrolment; brain MRI criteria suggestive of low myelin content but preserved tissue integrity in pre-existing T2 lesions; stably treated ≥24 weeks with interferon-beta, dimethyl fumarate, or natalizumab. Primary endpoint is the multicomponent Overall Response Score (based on EDSS, Timed 25-Foot Walk, and 9-Hole Peg Test). Secondary endpoints will evaluate confirmed improvement in disability measures.Results Enrolment began in September 2017 and was completed in September 2018. Participant baseline demographic, disease, and MRI characteristics will be presented.Conclusions AFFINITY will further investigate the efficacy and safety of opicinumab in a subpopulation of MS patients.Support: Biogen. Disclosures to be included on poster. ER -