PT - JOURNAL ARTICLE AU - McGurgan, Iain AU - Butt, Shahena AU - Silver, Louise AU - Werring, David AU - Rothwell, Peter TI - 269 Prevention of hypertensive injury to the brain by intensive treatment in intracerebral haemorrhage (PROHIBIT-ICH): protocol for a randomised controlled trial of telemetric home BP monitoring AID - 10.1136/jnnp-2019-ABN-2.214 DP - 2019 Dec 01 TA - Journal of Neurology, Neurosurgery & Psychiatry PG - e63--e64 VI - 90 IP - 12 4099 - http://jnnp.bmj.com/content/90/12/e63.3.short 4100 - http://jnnp.bmj.com/content/90/12/e63.3.full SO - J Neurol Neurosurg Psychiatry2019 Dec 01; 90 AB - Background Intracerebral haemorrhage (ICH) accounts for about 10% of strokes in the UK and is a major cause of severe disability and death. Sustained post-acute blood pressure (BP) management arguably holds the most potential to improve long-term prognosis, but there have been no trials to guide the optimal strategy for BP lowering after ICH. Telemetric home BP monitoring is a promising intervention to improve control.Methods 112 adult survivors of hypertension-related ICH across multiple UK sites will be randomised to intensive telemetric home BP monitoring-guided treatment (intervention) to achieve a target of <120/80 mmHg or standard care (control).OutcomesEfficacy: the magnitude of difference in BP at 3 months in the intervention arm versus the control arm compared with baseline measuresFeasibility: consent rate; dropout rate from the intervention prior to 1 month; patient approval of the monitoring processSafety: serious adverse events related to reducing BP in the intervention armConclusion The BP monitoring component of PROHIBIT-ICH will determine whether a strategy of intensive BP treatment guided by telemetric monitoring for an extended period of time after spontaneous ICH is feasible, safe and effective in reducing BP.