@article {Hostettler298, author = {Isabel Charlotte Hostettler and Matthew J Morton and Gareth Ambler and Nabila Kazmi and Tom Gaunt and Duncan Wilson and Clare Shakeshaft and H R J{\"a}ger and Hannah Cohen and Tarek A Yousry and Rustam Al-Shahi Salman and Gregory Lip and Martin M Brown and Keith Muir and Henry Houlden and Diederik O Bulters and Ian Galea and David J Werring}, editor = {, and , and Aeron-Thomas, John and Aghoram, Prasanna and Amis, Elaine and Anderton, Peter and Andole, Sreeman and Anwar, Ijaz and Bamford, John and Banaras, Azra and Barry, Aian and Bellfied, Ruth and Benford, Aienne and Bhalla, Ajay and Bhargava, Maneesh and Bhaskaran, Biju and Bhupathiraju, Neelima and Birns, Jonathan and Blight, Aian and Bowring, Angie and Brown, Ellen and Bruce, David and Buck, Amanda and Bunworth, Kerry and Burger, Ilse and Burgess, Laura and Burn, Mathew and Burssens, Evelyn and Burton, Mauian and Butler, Nicola and Button, Denise and Carpenter, Michael and Chadha, Dinesh and Chatterjee, Kausik and Choy, Lillian and Cohen, David and Connell, Lynne and Cooper, Martin and Corrigan, John and Cotterill, Donna and Courtauld, Gillian and Crawford, Susan and Cullen, Claire and Dani, Krishna and Daniel, Amelia and Daniel, Prabel and Davis, Michelle and Day, Nicola and Doherty, Mandy and Douglas, Catherine and Dunne, Karen and Edwards, Collette and Eglinton, Charlotte and Elmarimi, Abduelbaset and Elmarimi, Hedley and England, Timothy and Epstein, Daniel and Epstein, Renuka and Esisi, Bernard and Evans, Rachel and Farren, Pamela and Fitzell, Pauline and Fletcher, Glyn and Gallifent, Rachel and Gascoyne, Rachel and Giallombardo, Elio and Gregary, Bindu and Gunathilagan, Gunaratam and Guyler, Paul and Hairsine, Brigid and Haley, Michael and Hardwick, Anne and Hargroves, David and Harrington, Frances and Hedstrom, Amanda and Holmes, Clare and Hussein, Senussi and Ingram, Tanya and Ispoglou, Sissi and Iveson, Liz and Johnson, Venetia and Justin, Frances and Kausar, Shahid and Kee, Karen and Keeling, Michael and Khan, Shagufta and Kieliszkowska, Agnieszka and Kingwell, Hayley and Krishnamurthy, Vinodh and Kullane, Sagal and Kumar, Balakrishna and Leach, Simon and Leason, Sana and Lopez, Paula and Luder, Robert and Madigan, Barbara and Maguire, Stuart and Maguire, Holly and Mahawish, Karim and Makawa, Linetty and Mamun, Maam and Manawadu, Dulka and Mangion, David and Manoj, Aravindakshan and Mansoor, Syed and Marsden, Tracy and Marsh, Rachel and Mashate, Sheila and McCormick, Michael and McGolick, Clare and McKee, Madeleine and Mckenzie, Emma and Meenakishundaram, Sanjeevikumar and Mellor, Zoe and Misra, Amulya and Mistri, Amit and Nor, Azlisham Mohd and Mpelembue, Mushiya and Murphy, Peter and Nallasivam, Arumug and Needle, Ann and Nguyen, Vinh and O{\textquoteright}Connell, Janice and O{\textquoteright}Mahony, Paul and Okwera, James and Orefo, Chukwuka and Owusu-Agyei, Peter and Parry, Anthea and Parry-Jones, Adrian and Pasco, Kath and Patterson, Chris and Peixoto, Cassilda and Perez, Jane and Persad, Nicola and Porteous, Mia and Power, Michael and Price, Christopher and Proschel, Harald and Punekar, Shuja and Putterill, Janet and Randall, Marc and Redjep, Ozlem and Rehman, Habib and Richards, Emma and Riddell, Victoria and Roffe, Christine and Rogers, Gill and Rudd, Anthony and Saastamoinen, Kari and Sajid, Mahmud and Sandhu, Banher and Schofield, Christine and Scott, Jon and Sekaran, Lakshmanan and Sharma, Pankaj and Sharma, Jagdish and Sharpe, Simon and Smith, Matthew and Smith, Anew and Sprigg, Nikola and Staals, Julie and Steele, Amy and Storey, Gail and Storey, Kelley and Subramonian, Santhosh and Sword, Jane and Tallon, Grainne and Tan, Garryck and Tate, Margaret and Teke, Jennifer and Temple, Natalie and Thompson, Teresa and Tysoe, Sharon and Vahidassr, Djamil and Kwaak, Anouk van der and Veltkamp, Roland and Walstow, Deborah and Watchurst, Caroline and Watson, Fran and Waugh, Dean and Wilkinson, Peter and Wilson, David and Wilson-Owen, Sarah and Wroath, Belinda and Wynter, Inez and Young, Emma}, title = {Haptoglobin genotype and outcome after spontaneous intracerebral haemorrhage}, volume = {91}, number = {3}, pages = {298--304}, year = {2020}, doi = {10.1136/jnnp-2019-321774}, publisher = {BMJ Publishing Group Ltd}, abstract = {Objective Haptoglobin is a haemoglobin-scavenging protein that binds and neutralises free haemoglobin and modulates inflammation and endothelial progenitor cell function. A HP gene copy number variation (CNV) generates HP1 and HP2 alleles, while the single-nucleotide polymorphism rs2000999 influences their levels. The HP1 allele is hypothesised to improve outcome after spontaneous (non-traumatic) intracerebral haemorrhage (ICH). We investigated the associations of the HP CNV genotype and rs2000999 with haematoma volume, perihaematomal oedema (PHO) volume, functional outcome and mortality after ICH.Methods We included patients with neuroimaging-proven ICH, available DNA and 6-month follow-up in an observational cohort study (CROMIS-2). We classified patients into three groups according to the HP CNV: 1{\textendash}1, 2{\textendash}1 or 2{\textendash}2 and also dichotomised HP into HP1-containing genotypes (HP1-1 and HP2-1) and HP2-2 to evaluate the HP1 allele. We measured ICH and PHO volume on CT; PHO was measured by oedema extension distance. Functional outcome was assessed by modified Rankin score (unfavourable outcome defined as mRS 3{\textendash}6).Results We included 731 patients (mean age 73.4, 43.5\% female). Distribution of HP CNV genotype was: HP1-1 n=132 (18.1\%); HP2-1 n=342 (46.8\%); and HP2-2 n=257 (35.2\%). In the multivariable model mortality comparisons between HP groups, HP2-2 as reference, were as follows: OR HP1-1 0.73, 95\% CI 0.34 to 1.56 (p value=0.41) and OR HP2-1 0.5, 95\% CI 0.28 to 0.89 (p value=0.02) (overall p value=0.06). We found no evidence of association of HP CNV or rs200999 with functional outcome, ICH volume or PHO volume.Conclusion The HP2-1 genotype might be associated with lower 6-month mortality after ICH; this finding merits further study.}, issn = {0022-3050}, URL = {https://jnnp.bmj.com/content/91/3/298}, eprint = {https://jnnp.bmj.com/content/91/3/298.full.pdf}, journal = {Journal of Neurology, Neurosurgery \& Psychiatry} }