PT  - JOURNAL ARTICLE
AU  - Wei Xu
AU  - Chen-Chen Tan
AU  - Juan-Juan Zou
AU  - Xi-Peng Cao
AU  - Lan Tan
TI  - Sleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis
AID  - 10.1136/jnnp-2019-321896
DP  - 2020 Mar 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 236--244
VI  - 91
IP  - 3
4099  - http://jnnp.bmj.com/content/91/3/236.short
4100  - http://jnnp.bmj.com/content/91/3/236.full
SO  - J Neurol Neurosurg Psychiatry2020 Mar 01; 91
AB  - Objectives To conduct an updated systematic review and meta-analysis of association between sleep and all-cause cognitive disorders.Methods PubMed and EMBASE were searched from inception to 18 February 2019. Cohort studies exploring longitudinal associations of sleep with cognitive decline or dementia were included. The multivariable-adjusted effect estimates were pooled by random-effects models, with credibility assessment. The robust error meta-regression model was used to conduct the dose–response meta-analysis for sleep duration.Results 11 155 reports were searched and 51 eligible cohorts with 15 sleep problems were included for our meta-analyses. Ten types of sleep conditions or parameters, including six (insomnia, fragmentation, daytime dysfunction, prolonged latency, rapid eye movement sleep behaviour disorder and excessive time in bed) with moderate-to-high levels of evidence, were linked to higher risk of all-cause cognitive disorders. Furthermore, a U-shaped relationship was revealed for the associations with sleep duration.Conclusions Sleep management might serve as a promising target for dementia prevention.