RT Journal Article SR Electronic T1 Cognitive inhibition impairments in presymptomatic C9orf72 carriers JF Journal of Neurology, Neurosurgery & Psychiatry JO J Neurol Neurosurg Psychiatry FD BMJ Publishing Group Ltd SP 366 OP 372 DO 10.1136/jnnp-2019-322242 VO 91 IS 4 A1 Maxime Montembeault A1 Sabrina Sayah A1 Daisy Rinaldi A1 Benjamin Le Toullec A1 Anne Bertrand A1 Aurélie Funkiewiez A1 Dario Saracino A1 Agnès Camuzat A1 Philippe Couratier A1 Marianne Chouly A1 Didier Hannequin A1 Carole Aubier-Girard A1 Florence Pasquier A1 Xavier Delbeuck A1 Olivier Colliot A1 Bénédicte Batrancourt A1 Carole Azuar A1 Richard Lévy A1 Bruno Dubois A1 Isabelle Le Ber A1 Raffaella Migliaccio A1 , YR 2020 UL http://jnnp.bmj.com/content/91/4/366.abstract AB Objective To investigate cognitive inhibition in presymptomatic C9orf72 mutation carriers (C9+) and its associated neuroanatomical correlates.Methods Thirty-eight presymptomatic C9orf72 mutation carriers (C9+, mean age 38.2±8.0 years) and 22 C9− controls from the PREV-DEMALS cohort were included in this study. They underwent a cognitive inhibition assessment with the Hayling Sentence Completion Test (HSCT; time to completion (part B−part A); error score in part B) as well as a 3D MRI.Results C9+ individuals younger than 40 years had higher error scores (part B) but equivalent HSCT time to completion (part B−part A) compared to C9− individuals. C9+ individuals older than 40 years had both higher error scores and longer time to completion. HSCT time to completion significantly predicted the proximity to estimated clinical conversion from presymptomatic to symptomatic phase in C9+ individuals (based on the average age at onset of affected relatives in the family). Anatomically, we found that HSCT time to completion was associated with the integrity of the cerebellum.Conclusion The HSCT represents a good marker of cognitive inhibition impairments in C9+ and of proximity to clinical conversion. This study also highlights the key role of the cerebellum in cognitive inhibition.