RT Journal Article
SR Electronic
T1 Anti-MOG antibody–associated disorders: differences in clinical profiles and prognosis in Japan and Germany
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP jnnp-2020-324422
DO 10.1136/jnnp-2020-324422
A1 Liu, Jia
A1 Mori, Masahiro
A1 Zimmermann, Hanna
A1 Brandt, Alexander
A1 Havla, Joachim
A1 Tanaka, Satoru
A1 Sugimoto, Kazuo
A1 Oji, Satoru
A1 Uzawa, Akiyuki
A1 Asseyer, Susanna
A1 Cooper, Graham
A1 Jarius, Sven
A1 Bellmann-Strobl, Judith
A1 Ruprecht, Klemens
A1 Siebert, Nadja
A1 Masuda, Hiroki
A1 Uchida, Tomohiko
A1 Ohtani, Ryohei
A1 Nomura, Kyoichi
A1 Meinl, Edgar
A1 Kuempfel, Tania
A1 Paul, Friedemann
A1 Kuwabara, Satoshi
YR 2020
UL http://jnnp.bmj.com/content/early/2020/11/19/jnnp-2020-324422.abstract
AB Background Neurological disorders with IgG antibodies against myelin-oligodendrocyte glycoprotein (MOG-IgG) have been increasingly recognised as a new type of neuroinflammatory disorder.Objective The study aimed to identify regional and ethnic differences in clinical profiles of MOG-IgG–associated disorders between East Asian (Japanese) and Caucasian (German) patients.Methods Demographic, clinical and therapeutic data from 68 MOG-IgG–positive adults were collected (Japanese, n=44; German, n=24).Results Age and sex were similar between cohorts, with optic neuritis occurring most frequently at onset (Japanese: 61%; German: 58%). However, Japanese patients had a lower annualised relapse rate (0.4 vs 0.8, p=0.019; no relapse, 64% vs 25%, p=0.002) and lower Expanded Disability Status Scale score at the last visit (1.0 vs 2.0; p=0.008), despite similar follow-up periods (mean, 73.9 months vs 73.4 months), than those of German patients, respectively. Cerebral syndromes were more common (27% vs 4%; p=0.021) and myelitis less common (21% vs 50%; p=0.012) in Japanese than in German patients, respectively. Japanese patients were more commonly treated with long-term corticosteroids (73%), whereas German patients were more commonly treated with rituximab or other immunosuppressants (63%).Conclusions Among patients with MOG-IgG, Japanese tended to have a monophasic milder disease, whereas the majority of German patients had a relapsing course and more frequent myelitis, findings compatible with neuromyelitis optica spectrum disorder. Although the attack-prevention treatment regimens were considerably different, genetic and environmental factors may be important to determine clinical phenotypes and disease activity.