RT Journal Article
SR Electronic
T1 Trauma and depressive symptomatology in middle-aged persons at high risk of dementia: the PREVENT Dementia Study
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 16
OP 21
DO 10.1136/jnnp-2020-323823
VO 92
IS 1
A1 Karen Ritchie
A1 Isabelle Carrière
A1 Sarah Gregory
A1 Tam Watermeyer
A1 Samuel Danso
A1 Li Su
A1 Craig W Ritchie
A1 John T O'Brien
YR 2021
UL http://jnnp.bmj.com/content/92/1/16.abstract
AB Objective Depression and trauma are associated with changes in brain regions implicated in Alzheimer’s disease. The present study examined associations between childhood trauma, depression, adult cognitive functioning and risk of dementia.Methods Data from 378 participants in the PREVENT Dementia Study aged 40–59 years. Linear and logistic models were used to assess associations between childhood trauma, depression, dementia risk, cognitive test scores and hippocampal volume.Results Childhood trauma was associated with depression and reduced hippocampal volume but not current cognitive function or dementia risk. Poorer performance on a delayed face/name recall task was associated with depression. Childhood trauma was associated with lower hippocampal volume however poorer cognitive performance was mediated by depression rather than structural brain differences.Conclusion Depressive symptomatology may be associated with dementia risk via multiple pathways, and future studies should consider subtypes of depressive symptomatology when examining its relationship to dementia.