TY - JOUR T1 - In vivo PET imaging of neuroinflammation in familial frontotemporal dementia JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 231 LP - 231 DO - 10.1136/jnnp-2020-324348 VL - 92 IS - 3 AU - Harro Seelaar AU - John Cornelis Van Swieten Y1 - 2021/03/01 UR - http://jnnp.bmj.com/content/92/3/231.abstract N2 - There is increasing clinical, genetic, molecular and cellular evidence that neuroinflammation plays an important role in sporadic and genetic frontotemporal dementia (FTD), with mutations in Progranulin (GRN), microtubule-associated protein tau (MAPT) or repeat expansions in chromosome nine open reading frame 72 (C9orf72).1 GRN and C9orf72 are highly expressed in microglia.2 Genes involved in immune pathways are significantly associated with FTD, and upregulated expression of astrocytic and microglial proteins are found in FTD brains. Furthermore, higher levels of neuroinflammatory biomarkers are found in the cerebrospinal fluid (CSF) of patients with FTD compared with controls or presymptomatic mutation carriers.2 Translocator protein 18 kDa (TSPO) positron emission tomography (PET) ligands are used as … ER -