TY - JOUR T1 - Anti-MOG antibody–associated disorders: differences in clinical profiles and prognosis in Japan and Germany JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 377 LP - 383 DO - 10.1136/jnnp-2020-324422 VL - 92 IS - 4 AU - Jia Liu AU - Masahiro Mori AU - Hanna Zimmermann AU - Alexander Brandt AU - Joachim Havla AU - Satoru Tanaka AU - Kazuo Sugimoto AU - Satoru Oji AU - Akiyuki Uzawa AU - Susanna Asseyer AU - Graham Cooper AU - Sven Jarius AU - Judith Bellmann-Strobl AU - Klemens Ruprecht AU - Nadja Siebert AU - Hiroki Masuda AU - Tomohiko Uchida AU - Ryohei Ohtani AU - Kyoichi Nomura AU - Edgar Meinl AU - Tania Kuempfel AU - Friedemann Paul AU - Satoshi Kuwabara Y1 - 2021/04/01 UR - http://jnnp.bmj.com/content/92/4/377.abstract N2 - Background Neurological disorders with IgG antibodies against myelin-oligodendrocyte glycoprotein (MOG-IgG) have been increasingly recognised as a new type of neuroinflammatory disorder.Objective The study aimed to identify regional and ethnic differences in clinical profiles of MOG-IgG–associated disorders between East Asian (Japanese) and Caucasian (German) patients.Methods Demographic, clinical and therapeutic data from 68 MOG-IgG–positive adults were collected (Japanese, n=44; German, n=24).Results Age and sex were similar between cohorts, with optic neuritis occurring most frequently at onset (Japanese: 61%; German: 58%). However, Japanese patients had a lower annualised relapse rate (0.4 vs 0.8, p=0.019; no relapse, 64% vs 25%, p=0.002) and lower Expanded Disability Status Scale score at the last visit (1.0 vs 2.0; p=0.008), despite similar follow-up periods (mean, 73.9 months vs 73.4 months), than those of German patients, respectively. Cerebral syndromes were more common (27% vs 4%; p=0.021) and myelitis less common (21% vs 50%; p=0.012) in Japanese than in German patients, respectively. Japanese patients were more commonly treated with long-term corticosteroids (73%), whereas German patients were more commonly treated with rituximab or other immunosuppressants (63%).Conclusions Among patients with MOG-IgG, Japanese tended to have a monophasic milder disease, whereas the majority of German patients had a relapsing course and more frequent myelitis, findings compatible with neuromyelitis optica spectrum disorder. Although the attack-prevention treatment regimens were considerably different, genetic and environmental factors may be important to determine clinical phenotypes and disease activity. ER -