TY - JOUR T1 - Deep brain stimulation ‘probably’ works on patients with tardive syndromes JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry DO - 10.1136/jnnp-2021-326028 SP - jnnp-2021-326028 AU - Chencheng Zhang AU - Bomin Sun Y1 - 2021/03/15 UR - http://jnnp.bmj.com/content/early/2021/03/14/jnnp-2021-326028.abstract N2 - Tardive syndromes (TDS) refer to the clinical spectrum of persistent hyperkinetic, hypokinetic and sensory phenomena that stem from chronic exposure to dopamine receptor-blocking drugs. Correspondingly, the clinical presentation of three times a day is diverse. Although three times a day have been a major area of movement disorder clinical practice for decades, their pathophysiological bases remain poorly understood, and the optimal treatment approach for patients affected by these disabling disorders remains unclear.1Functional neurosurgery has gained increasing recognition as a viable treatment option for severe and medication-refractory cases of three times a day. However, deep brain stimulation (DBS) for TDS is a challenging treatment due to the presence of multiple … ER -