TY - JOUR T1 - Remyelination and neuroprotective effects of alemtuzumab therapy in patients with multiple sclerosis JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 1251 LP - 1251 DO - 10.1136/jnnp-2021-326821 VL - 92 IS - 12 AU - Hiroki Masuda AU - Masahiro Mori AU - Satoshi Kuwabara Y1 - 2021/12/01 UR - http://jnnp.bmj.com/content/92/12/1251.abstract N2 - Multiple sclerosis (MS) is a demyelinating, inflammatory and potentially degenerative disorder of the central nervous system. Whereas, an initial event triggers immune-mediated demyelination in MS, in the secondary progressive phase, axonal degeneration is thought to be due to impaired axo-glial interaction, which leads to a gradual worsening of the disability. In the development of an efficient therapeutic strategy for MS, stimulating or enhancing remyelination is important because remyelination leads to improvement in impulse transmission and metabolic support to the underlying axon.1 Clemastine fumarate and opicinumab, which both target remyelination, have been reported to show reduced visual evoked potentials (VEP) latency in patients with MS and optic neuritis, … ER -