TY - JOUR T1 - Early lowering of blood pressure after acute intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 6 LP - 13 DO - 10.1136/jnnp-2021-327195 VL - 93 IS - 1 AU - Tom J Moullaali AU - Xia Wang AU - Else Charlotte Sandset AU - Lisa J Woodhouse AU - Zhe Kang Law AU - Hisatomi Arima AU - Kenneth S Butcher AU - John Chalmers AU - Candice Delcourt AU - Leon Edwards AU - Salil Gupta AU - Wen Jiang AU - Sebastian Koch AU - John Potter AU - Adnan I Qureshi AU - Thompson G Robinson AU - Rustam Al-Shahi Salman AU - Jeffrey L Saver AU - Nikola Sprigg AU - Joanna M Wardlaw AU - Craig S Anderson AU - Philip M Bath A2 - , Y1 - 2022/01/01 UR - http://jnnp.bmj.com/content/93/1/6.abstract N2 - Objective To summarise evidence of the effects of blood pressure (BP)-lowering interventions after acute spontaneous intracerebral haemorrhage (ICH).Methods A prespecified systematic review of the Cochrane Central Register of Controlled Trials, EMBASE and MEDLINE databases from inception to 23 June 2020 to identify randomised controlled trials that compared active BP-lowering agents versus placebo or intensive versus guideline BP-lowering targets for adults <7 days after ICH onset. The primary outcome was function (distribution of scores on the modified Rankin scale) 90 days after randomisation. Radiological outcomes were absolute (>6 mL) and proportional (>33%) haematoma growth at 24 hours. Meta-analysis used a one-stage approach, adjusted using generalised linear mixed models with prespecified covariables and trial as a random effect.Results Of 7094 studies identified, 50 trials involving 11 494 patients were eligible and 16 (32.0%) shared patient-level data from 6221 (54.1%) patients (mean age 64.2 [SD 12.9], 2266 [36.4%] females) with a median time from symptom onset to randomisation of 3.8 hours (IQR 2.6–5.3). Active/intensive BP-lowering interventions had no effect on the primary outcome compared with placebo/guideline treatment (adjusted OR for unfavourable shift in modified Rankin scale scores: 0.97, 95% CI 0.88 to 1.06; p=0.50), but there was significant heterogeneity by strategy (pinteraction=0.031) and agent (pinteraction<0.0001). Active/intensive BP-lowering interventions clearly reduced absolute (>6 ml, adjusted OR 0.75, 95%CI 0.60 to 0.92; p=0.0077) and relative (≥33%, adjusted OR 0.82, 95%CI 0.68 to 0.99; p=0.034) haematoma growth.Interpretation Overall, a broad range of interventions to lower BP within 7 days of ICH onset had no overall benefit on functional recovery, despite reducing bleeding. The treatment effect appeared to vary according to strategy and agent.PROSPERO registration number CRD42019141136.Data are available in a public, open access repository. Data are available on reasonable request. Requests for sharing of de-identified IPD from individual trials used in these analyses should be directed to the corresponding author of the individual trial. The ATACH-II trial data, including de-identified participant data, are available indefinitely at the National Institute of Neurological Disorders and Stroke data archive (https://www.ninds.nih.gov/). To gain access, requesters will need to sign a data-access agreement. ER -