RT Journal Article
SR Electronic
T1 Axonal degeneration in chemotherapy-induced peripheral neurotoxicity: clinical and experimental evidence
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 962
OP 972
DO 10.1136/jnnp-2021-328323
VO 94
IS 11
A1 Park, Susanna B
A1 Cetinkaya-Fisgin, Aysel
A1 Argyriou, Andreas A
A1 Höke, Ahmet
A1 Cavaletti, Guido
A1 Alberti, Paola
YR 2023
UL http://jnnp.bmj.com/content/94/11/962.abstract
AB Multiple pathological mechanisms are involved in the development of chemotherapy-induced peripheral neurotoxicity (CIPN). Recent work has provided insights into the molecular mechanisms underlying chemotherapy-induced axonal degeneration. This review integrates evidence from preclinical and clinical work on the onset, progression and outcome of axonal degeneration in CIPN. We review likely triggers of axonal degeneration in CIPN and highlight evidence of molecular pathways involved in axonal degeneration and their relevance to CIPN, including SARM1-mediated axon degeneration pathway. We identify potential clinical markers of axonal dysfunction to provide early identification of toxicity as well as present potential treatment strategies to intervene in axonal degeneration pathways. A greater understanding of axonal degeneration processes in CIPN will provide important information regarding the development and progression of axonal dysfunction more broadly and will hopefully assist in the development of successful interventions for CIPN and other neurodegenerative disorders.