RT Journal Article
SR Electronic
T1 The influence of epigenetic biological age on key complications and outcomes in aneurysmal subarachnoid haemorrhage
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 675
OP 681
DO 10.1136/jnnp-2023-332889
VO 95
IS 7
A1 Macias-Gómez, Adrià
A1 Jiménez-Balado, Joan
A1 Fernández‑Pérez, Isabel
A1 Suárez‑Pérez, Antoni
A1 Vallverdú-Prats, Marta
A1 Guimaraens, Leopoldo
A1 Vivas, Elio
A1 Saldaña, Jesus
A1 Giralt-Steinhauer, Eva
A1 Guisado-Alonso, Daniel
A1 Villalba, Gloria
A1 Gracia, Maria-Pilar
A1 Esteller, Manel
A1 Rodriguez-Campello, Ana
A1 Jiménez-Conde, Jordi
A1 Ois, Angel
A1 Cuadrado-Godia, Elisa
YR 2024
UL http://jnnp.bmj.com/content/95/7/675.abstract
AB Background We aimed to investigate the association between DNA-methylation biological age (B-age) calculated as age acceleration (ageAcc) and key aneurysmal subarachnoid haemorrhage (aSAH) complications such as vasospasm, delayed cerebral ischaemia (DCI), poor outcome, and mortality.Methods We conducted a prospective study involving 277 patients with aSAH. B-age was determined in whole blood samples using five epigenetic clocks: Hannum’s, Horvath’s, Levine’s and both versions of Zhang’s clocks. Age acceleration was calculated as the residual obtained from regressing out the effect of C-age on the mismatch between C-age and B-age. We then tested the association between ageAcc and vasospasm, DCI and 12-month poor outcome (mRS 3–5) and mortality using linear regression models adjusted for confounders.Results Average C-age was 55.0 years, with 66.8% being female. Vasospasm occurred in 143 cases (51.6%), DCI in 70 (25.3%) and poor outcomes in 99 (35.7%), with a mortality rate of 20.6%. Lower ageAcc was linked to vasospasm in Horvath’s and Levine’s clocks, whereas increased ageAcc was associated with 12-month mortality in Hannum’s clock. No significant differences in ageAcc were found for DCI or poor outcome at 12 months with other clocks.Conclusions Our study indicates that B-age is independently associated with vasospasm and 12-month mortality in patients with aSAH. These findings underscore the potential role of epigenetics in understanding the pathophysiology of aSAH-related complications and outcomes.Data are available upon reasonable request.