Table 1

Overview of peripheral neuropathy (PN) patients

Patient noClinical manifestationsMain laboratory findingsPN present at SS diagnosisNeurological findingsNeuropathy
MotorSensoryDeep tendon reflexes
7Mild sicca onlyANA, anti-Ro, anti-La, RF+NormalPP, LT deficits, of the upper digits and soles, POS, Vib deficits of the distal lower limbsAbsent globallyAxonal sensory
24Mild sicca onlyANA, anti-Ro, RF, low C4NormalPP, LT LL deficits distallyTriceps, Achilles diminishedAxonal sensory
10Sicca, Raynaud phenomenon, vasculitis, purpura, PGE, atrophic gastritisANA, anti-Ro, anti-La, RF, anaemia, low C4, cryoglobulinaemia+Distal right UL muscle weakness (4/5)PP, LT deficits in UL and LLLeft triceps and bilateral Achilles reflexes absentAxonal sensorimotor
28Sicca, arthritis, Raynaud phenomenon, purpura, PGEANA, anti-Ro, AMA, anti-U1RNP, anaemiaNormalVib, POS deficits globallyAbsent in LLAxonal sensory
30Sicca, arthritisANA, anti-Ro, RFProximal and distal bilateral UL and LL muscle weakness (4/5)NormalAbsent in right UL and LL bilaterallyAxonal sensorimotor
32Sicca, arthralgias, PGE, lymphadenopathyANA, anti-Ro, anaemia, low C4NormalLT, PP deficits in right distal LLAchilles tendon reflexes absent bilaterallyAxonal sensory
33Sicca, purpura, vasculitisANA, anti-Ro, cryoglobulinaemia, low C4Right LL distal muscle weakness (4/5)Vib deficits in LL bilaterallyAbsent Achilles deep tendon reflexesAxonal sensory with superimposed acute mononeuropathy
34Sicca, Arthralgias, Raynaud phenomenon, purpura, PGE, glomerulonephritisANA, anaemiaProximal and distal muscle weakness in all limbs (4/5, except distal right LL 2/5)PP, LT deficits in distal right LLBilaterally absent Achilles reflexesAxonal sensorimotor
43Sicca, Arthralgias, Raynaud phenomenon, vasculitis, purpura, lymphadenopathyANA, anti-Ro, RF, anaemia, cryoglobulinaemia, low C4+Distal symmetrical LL muscle weaknessPP and LT deficits in distal LLNormalAxonal sensorimotor
  • ANA, antinuclear antibodies; LL, lower limbs; LT, light touch; Pos, position sensation deep tendon reflexes, deep; PP, pinprick; RF, rheumatoid factor; SS, Sjögren syndrome; UL, upper limbs; Vib, vibration sensation.