Patient no | Clinical manifestations | Main laboratory findings | PN present at SS diagnosis | Neurological findings | Neuropathy | ||
Motor | Sensory | Deep tendon reflexes | |||||
7 | Mild sicca only | ANA, anti-Ro, anti-La, RF | + | Normal | PP, LT deficits, of the upper digits and soles, POS, Vib deficits of the distal lower limbs | Absent globally | Axonal sensory |
24 | Mild sicca only | ANA, anti-Ro, RF, low C4 | – | Normal | PP, LT LL deficits distally | Triceps, Achilles diminished | Axonal sensory |
10 | Sicca, Raynaud phenomenon, vasculitis, purpura, PGE, atrophic gastritis | ANA, anti-Ro, anti-La, RF, anaemia, low C4, cryoglobulinaemia | + | Distal right UL muscle weakness (4/5) | PP, LT deficits in UL and LL | Left triceps and bilateral Achilles reflexes absent | Axonal sensorimotor |
28 | Sicca, arthritis, Raynaud phenomenon, purpura, PGE | ANA, anti-Ro, AMA, anti-U1RNP, anaemia | – | Normal | Vib, POS deficits globally | Absent in LL | Axonal sensory |
30 | Sicca, arthritis | ANA, anti-Ro, RF | – | Proximal and distal bilateral UL and LL muscle weakness (4/5) | Normal | Absent in right UL and LL bilaterally | Axonal sensorimotor |
32 | Sicca, arthralgias, PGE, lymphadenopathy | ANA, anti-Ro, anaemia, low C4 | – | Normal | LT, PP deficits in right distal LL | Achilles tendon reflexes absent bilaterally | Axonal sensory |
33 | Sicca, purpura, vasculitis | ANA, anti-Ro, cryoglobulinaemia, low C4 | – | Right LL distal muscle weakness (4/5) | Vib deficits in LL bilaterally | Absent Achilles deep tendon reflexes | Axonal sensory with superimposed acute mononeuropathy |
34 | Sicca, Arthralgias, Raynaud phenomenon, purpura, PGE, glomerulonephritis | ANA, anaemia | – | Proximal and distal muscle weakness in all limbs (4/5, except distal right LL 2/5) | PP, LT deficits in distal right LL | Bilaterally absent Achilles reflexes | Axonal sensorimotor |
43 | Sicca, Arthralgias, Raynaud phenomenon, vasculitis, purpura, lymphadenopathy | ANA, anti-Ro, RF, anaemia, cryoglobulinaemia, low C4 | + | Distal symmetrical LL muscle weakness | PP and LT deficits in distal LL | Normal | Axonal sensorimotor |
ANA, antinuclear antibodies; LL, lower limbs; LT, light touch; Pos, position sensation deep tendon reflexes, deep; PP, pinprick; RF, rheumatoid factor; SS, Sjögren syndrome; UL, upper limbs; Vib, vibration sensation.