Table 3

Global judgements (number of patients (%))

Neuroleptic naiveNeuroleptic treated
Clozapine (n=7) Placebo (n=11)
Clozapine (n=4) Placebo (n=4)
Video rating of choreatic movements:
Worse1 (9)2 (50)2 (50)
 Unchanged4 (57)5 (45)1 (25)1 (25)
 Improved3 (43)5 (45)1 (25)1 (25)
Patient’s judgement of last trial week:
Worse2 (29)3-150 1 (9)1 (25)3-150 2 (50)
 Unchanged2 (29)6 (55)2 (50)1 (25)
 Improved3 (43)4 (36)1 (25)1 (25)
  • 3-150 Four patients (two neuroleptic naive, two neuroleptic treated) experienced subjective complaints severe enough to force trial suspension (see table 4). Correcting the presented figures for their judgements, 44% of neuroleptic naive and 50% of neuroleptic treated patients would judge the last week of the trial as worse.