Severity of adverse effects (number of patients)
| Clozapine (n=17) | Placebo (n=16) | |
|---|---|---|
| No adverse effects | — | 114-150 |
| Mild (no consequences) | 3 | 4 |
| Moderate (dose reduction necessary) | 84-151 | 1 |
| Severe (trial suspension necessary) | 64-152 | — |
↵4-150 Trial suspension forced by intercurrent illness in one patient.
↵4-151 Reason for dose reduction (number of patients): drowsiness (three); confusion (one); urinary incontinence (one); walking difficulties (one); dizziness (one); increased liver enzymes (one).
↵4-152 Reason for trial suspension (number of patients): urinary incontinence (one); walking/speaking difficulties (one); orthostatic hypotension/syncope (one); increased liver enzymes (two); epileptic seizure (one).