Table 1

MRI1-150 findings in patients and historical factors in patients’ uses of l-tryptophan (l-T)

Patient NoAgeMRI findingReason for taking
Other historyMRI time from onset of symptomsMRI time from neuropsychological examination
131NABoost metabolism and energyNone
2381-151 No abnormalitiesPain due to TMJNone22 months1 month
3421-151 NAInsomnia due to birth of babyNone
5431-151 Mild atrophy: slightly prominent CSF spacesInsomniaNone27 months3 months
6431-151 NADepressionNone
743Multiple (> 25) white matter lesions throughout all lobes, more lobes, patchy areas in pons, single lesions right frontal region near genu of the corpus callosumInsomnia due to work stressNone52 months2 months
8431-151 Multiple white matter hyperintensitiesPMSNone28 months0.5 months
944NAInsomnia due to workNone
1044No abnormalitiesInsomniaHistory of substance misuse, no current use60 months6 months
1246Multiple hyperintensities in white matter and ponsInsomniaNone30 months7 months
1346NADietary supplement with hypertensive medicationsObsessive-compulsive history
1447NAAnxietyLong term prescribed benzodiazepine use
1549NAPain from orthopaedic injuryNone
1650Abnormally prominent Virchow-Robin spacesInsomnia due to family illnessNone59 monthsSame day
1750Small hyperintensities in white matter of left frontal lobe and ponsStress due to surgery and family problemsNone80 months28 months
1850No abnormalitiesPain due to orthopaedic problemsNone41 months2 months
1954NADepressed mood, insomnia, PMSHistory of alcoholism; no current use
2055Multiple white matter hyperintensities bilaterally in frontal and parietal lobes, equivocal pons lesionsAid for sleepNone8 months39 months
2156NAPain due to back injuryCalcified parasagittal meningioma 8 years earlier, no other abnormalities
22561-151 Right cerebellar infarct; moderate to large areas of hyperintensities bilaterally in the mid-pons and lower pons, very small, multiple hyperintensities bilaterally in white matter of frontal, parietal, and occipital lobes, in right cerebellar cortexInsomnia due to injury of dependent family memberNone24 months7 months
2358Few small punctate lesions in frontal white matter and frontoparietal regionStress due to political electionNone41 months7 months
  • 1-150 MRI was obtained at several different imaging centres, on 1.5 Tesla magnets, with standard clinical sequences (sagittal and axial T1 weighted, axial and coronal T2 weighted images). No contrast agent was used in any scan.

  • 1-151 Patients available for re-evaluation.

  • NA = not available because patient had not been scanned; TMJ = temporomandibular joint syndrome; PMS = premenstrual syndrome.