Testing for coagulation and thrombophilia indices in four patients with postdural puncture cerebral venous sinus thrombosis

Index (units; normal values)Patient 2Patient 3Patient 4Patient 5
Platelets (× 10−9/l; 125-320)158237243327
Factor V:C (%; 70-130)7999112150
Factor II:C (%; 70-130)ND79100132
Factor VII:C (%; 70-130)ND10664189
Factor X:C (%; 70-130)ND85112156
Fibrinogen (g/l; 1.5-3.0)1.72.42.12.8
TAT-complex (μg/l; ⩽ 4.1)< 23.22.62.8
aPTT (s; 40-60)47513040
Antithrombin III activity (%; 80-120)10610598123
Plasminogen activity (%; 70-130)1128110988
Protein C activity:
 aPTT method (%; 65-135)739696131
 Chromogenic substrate (%; 65-135)ND91108153
Protein S free antigen (%)* 83 70 134 100
Protein S total antigen (%)* 113 88 136 136
Euglobulin clot lysis test (min):
 Before venous occlusion (> 240)> 240ND> 240> 240
 After venous occlusion (⩽ 100)173ND> 240> 240
APC resistance:
 Basal aPTT (s)33.637.934.527.4
 Ratio (2.02-3.73)2.042.091.932.40
Factor V R506Q (FV Leiden)HeterozygousHeterozygousHeterozygousNormal
  • ND = not done; * Protein S has different normal values for women (free antigen 55%-120%, total antigen 65%-118%) and men (free antigen 67%-153%, total antigen 73%-134%).