Clinical characteristics of relapsing–remitting multiple sclerosis patients with or without comorbid major depressive disorder
| RRMS (n=34) | RRMS+MDD (n=10) | p Value | |
| Age | 35.8+0.7 | 37.2+2.2 | 0.47 |
| Education (years) | 12.2+0.5 | 11.5+0.7 | 0.47 |
| Marital status (Single/Married/Rel/Div) | 5/19/8/2 | 3/4/3/0 | 0.49 |
| Employment (FT/PT/Unemployed) | 18/6/8 | 4/2/4 | 0.62 |
| Body mass index (kg/m2) | 25.2+1.1 | 24.6+1.8 | 0.79 |
| Day in menstrual cycle | 11.5+1.5 | 9.3+3.5 | 0.50 |
| Smoking (pack years) | 7.1+1.3 | 11.1+3.2 | 0.17 |
| Disease duration (years) | 7.8+0.6 | 8.4+1.6 | 0.66 |
| Disability (EDSS) | 2.2+0.2 | 3.3+0.3 | 0.01 |
| Progression Index | 0.4+0.1 | 0.7+0.2 | 0.10 |
| DMT (none/IFN/GA) | 13/9/12 | 5/4/1 | 0.30 |
| HADS depression | 2.3+0.5 | 11.7+1.1 | <0.001 |
| HADS anxiety | 4.9+0.6 | 10.1+1.2 | <0.001 |
| Fatigue | 14.7+3.0 | 45.9+4.2 | <0.001 |
Progression Index is the EDSS disability increase per year since diagnosis.
Div, divorced or separated; DMT, disease modifying therapy; EDSS, Expanded Disability Status Scale; FT, full time employment; GA, glatiramer acetate; HADS, Hospital Anxiety and Depression Scale; IFN, interferon; MDD, major depressive disorder; PT, part time employment; Rel, in a relationship; RRMS, relapsing–remitting multiple sclerosis.