Table 1

Characteristics of the appraised studies

StudiesCentreProspective data collectionProtocolProtocol violationsLosses to follow-up
Toni15Multi, ItalyNINDSDescribed (p=0.59)Not described
Uyttenboogaart17Single, NetherlandsNINDSNot describedNot described
Gómez-Choco18Single, SpainNINDSNot describedNot described
Meseguer19Single, FranceNINDSDescribed (p=1.0)Described
Ringleb13Single, GermanyLocalNot describedNot described
Mouradian11Single, CanadaNationalNot describedNot described
Berrouschot14Multi, GermanyNINDSDescribed (p=0.67)Not described
Engelter16Multi, SwitzerlandNINDSDescribed (p=0.43)Not described
Sylaja12Multi, CanadaNINDSDescribed (p=0.26)Not described
Oostenbrugge20Single, NetherlandsNINDSNot describedNot described
Parnetti21Single, ItalyNINDS + EUSIDescribed (no difference detected)Described
Tanne10Multi, USANINDSDescribed (p=0.03)None
Chen9Single, USANINDSNot describedNone
  • EUSI, European Stroke Initiative recommendations for stroke management—update 2003; NINDS, National Institute of Neurological Diseases and Stroke.