Table 2

Three month outcome of baclofen and placebo for severe spasticity (n=22)

Baseline score Mean (SD)
1   2
After 3 months Mean (SD) 
3    4
Effect size
5
Wilcoxon matched pairs signed ranksMann-Whitney U Wilcoxon rank sumEffect size
10
z Value
6
P value
7
z Value
8
P value
9
Clinical efficacy:
 Spasm score:
  Baclofen2.23  (0.54)1.65  (1.11)0.74−1.78 2-150 −2.32 2-150 0.20
  Placebo1.83 (0.66)1.81 (0.76)−0.18NS
 Ashworth scale:
  Baclofen2.51 (0.70)1.51 (1.20)1.12−1.99 2-150 −2.49 ** 1.40
  Placebo3.07 (0.41)2.87 (0.57)−1.25NS
 Self reported pain score:
  Baclofen4.20 (2.98)2.75 (3.22)0.72−1.35NS−1.79 2-150 0.94
  Placebo6.00 (3.07)5.94 (3.57)0.00NS
SIP§:
 Sleep and rest:
  Baclofen12.33 (12.27)16.20 (10.35)0.71−1.99 2-150 −1.21NS
  Placebo21.71 (16.84)21.38 (11.09)−0.10NS
 Mobility:
  Baclofen31.99 (17.40)16.69 (12.29)1.35−2.50 ** −2.32NS
  Placebo38.84 (24.09)35.88 (24.60)−0.42NS
 Physical dimension:
  Baclofen39.98 (9.78)35.10 (5.41)1.07−1.99 2-150 −1.31NS
  Placebo42.80 (12.73)39.53 (11.49)−1.54NS
 Psychosocial dimension:
  Baclofen16.03 (13.69)12.26 (9.87)0.74−1.68 2-150 −0.73NS
  Placebo42.80 (12.73)39.53 (11.49)−0.06NS
 SIP overall score:
  Baclofen31.72 (9.80)27.79 (5.32)1.00−1.78 2-150 −0.82NS
  Placebo30.12 (10.64)28.98 (8.83)−0.18NS
HSCL:
 Physical health:
  Baclofen4.17 (3.16)4.00 (3.44)−1.01NS−0.076NS
  Placebo5.78 (4.05)4.44 (3.00)−0.82NS
 Mental health:
  Baclofen7.83 (4.97)5.00 (4.28)1.28−2.50 ** −0.086NS
  Placebo6.89 (7.20)7.33 (6.69)−0.10NS
 HSCL overall score:
  Baclofen30.0 (12.54)20.67 (11.78)1.34−2.79 *** −0.099NS
  Placebo31.0 (21.62)28.22 (18.43)−0.82NS
  • 2-150 P < 0.05; ** P < 0.01; *** P < 0.001. Effect size for paired observations. Effect size for independent samples. §sickness impact profile. Hopkins symptoms check list.