Table 3

Effects of activating manoeuvres on BP and HR (mean (SEM))

Group I: levodopa only (n=9)Group II: selegiline and levodopa (n=16)Group II: selegiline ceased (n=16)
Valsalva ratio1.13  (0.03)1.15  (0.03)1.07  (0.02)e
R:R ratio with deep breathing4.9 (1.5)4.3 (0.7)5.2 (1.0)
Mental arithmetic
% Change in systolic BP5.4 (2.5)2.2 (5.5)1.9 (3.0)
% Change in diastolic BP6.0 (4.9)3.1 (2.1)−3.0 (1.8)
% Change in HR7.9 (2.4)6.8 (1.8)5.3 (2.5)
Response to cold face pack
% Change in systolic BP1.8 (3.7)−2.3 (3.2)6.7 (3.3)
% Change in diastolic BP−0.4 (1.9)−5.3 (6.3)3.8 (4.0)
% Change in HR−2.0 (1.2)−0.8 (1.3)−2.4 (1.4)
Cold pressor test
% Change in systolic BP4.7 (2.1)−0.5 (3.3)NA
% Change in diastolic BP−0.1 (14.0)−1.2 (2.7)NA
% Change in HR2.9 (2.5)2.5 (0.9)−3.0 (1.7)f
  • As absolute and percentage changes were similar, only the percentage changes are shown. No activating procedure affected blood pressure or heart rate in either group (P>0.05, paired ttest). Selegiline did not affect any autonomic function (comparison between groups I and II: P>0.05, two tailed t test), but its withdrawal mildly reduced the Valsalva ratio and reversed the heart rate response to the cold pressor test (eP<0.05;fP<0.01, paired ttest). However, drug withdrawal did not cause any of these indices to differ from those treated with levodopa alone (P>0.05, pairedt test). NA = not available; BP = blood pressure; HB = heart rate.