Table 2

Adverse events (n (%))

Adverse eventsPlacebo (n=20)250 units (n=19)500 units (n=17)1000 units (n=18)All groups (74)
Patients with adverse events5  (25)7  (37)11  (65)15  (83)2-150 37  (50)
Adverse events716244794
Dysphagia/swallowing problems (n (%))2 (10)4 (21)5 (29)7 (39)18 (24)
Neck weakness02 (11)2 (12)10 (56)** 14 (19)
Dry mouth1 (5)4 (21)3 (18)6 (33)14 (19)
Discomfort at injection site2 (10)1 (5)3 (18)5 (28)11 (15)
Tiredness1 (5)3 (16)2 (12)3 (17)9 (12)
Voice change/hoarseness003 (18)5 (28)2-150 8 (11)
Visual difficulty/blurring001 (6)3 (17)4 (5)
Jaw weakness01 (5)02 (11)3 (4)
Vertigo/dizziness001 (6)2 (11)3 (4)
Respiratory difficulty0001 (6)1 (1)
Respiratory infection0001 (6)1 (1)
Fever0001 (6)1 (1)
Diarrhoea0001 (6)1 (1)
Headache001 (6)01 (1)
Concentration problem001 (6)01 (1)
Feel mad001 (6)01 (1)
Itching001 (6)01 (1)
Increased sweating01 (5)001 (1)
Nausea/vertigo1 (5)0001 (1)
  • 2-150 Significant difference from placebo and 250 unit arms;**significant difference from placebo, 250, and 500 unit arms.

  • Units=units of Dysport®.