Comparison of patients with axonal and demyelinating neuropathy associated with monoclonal gammopathy: signs
| A-MGUS (n= 16) Mean (SD) | D-MGUS (n=20) Mean (SD) | P value | |
|---|---|---|---|
| MRC score | 4.5 (0.6) | 4.4 (0.4) | NS |
| Sensory score2-150: | |||
| Vibratory loss UL | 2.4 (0.6) | 1.8 (0.7) | 0.005 |
| Vibratory loss LL | 1.2 (0.9) | 1.0 (0.9) | NS |
| Proprioceptive loss UL | 2.8 (0.5) | 2.8 (0.4) | NS |
| Proprioceptive loss LL | 2.6 (0.6) | 2.2 (0.6) | 0.02 |
| LL ataxia | 0 | 11 | 0.0006 |
| Generalised areflexia | 3 | 14 | 0.003 |
| Rankin score | 2.1 (0.8) | 2.8 (0.8) | 0.007 |
| Anti-MAG antibodies | 0 | 8 | 0.004 |
| IgM gammopathy | 3 | 14 | 0 .0006 |
| CSF protein (mg/dl) | 49 (26) | 100 (55) | 0.02 |
↵2-150 Sensory scoring system: 3 = normal; 2 = impaired at fingertip or great toe; 1= impaired at PIP joint or ankle; 0 = impaired proximal to the PIP joint or above the ankle. LL = Lower limb; UL = Upper limb; MGUS = monoclonal gammopathy of undetermined significance.
The Mann-Whitney independent rank sum test was used to compare ordinal and continuous variables. Fisher’s exact test was used to compare categorical responses.