Comparison of patients with axonal and demyelinating neuropathy associated with monoclonal gammopathy: response to treatment and outcome
| A-MGUS (n= 16) Mean (SD) | D-MGUS (n=20) Mean (SD) | P value | |
|---|---|---|---|
| Response to treatment4-150: | |||
| Response to plasma exchange | 2/7 | 13/17 | 0.01 |
| Response to IVIg | 0/5 | 5/13 | NS |
| Response to steroids | 1/7 | 2/8 | NS |
| Follow up average MRC score | 4.5 (0.51) | 4.5 (0.54) | NS |
| Follow up Rankin score | 2.2 (0.98) | 2.1 (0.94) | NS |
| Mean change in Rankin score after treatment | 0.13 | -0.75 | 0.004 |
| Course: | |||
| Progressive | 15 | 14 | NS |
| Relapsing | 1 | 6 | NS |
MGUS = Monoclonal gammopathy of undetermined significance.
↵4-150 Several patients with a relapsing course were treated and responded to more than one treatment modality. The Mann-Whitney independent rank sum test was used to compare ordinal and continuous variables. Fisher’s exact test was used to compare categorical responses.