Treatment group (n (%)) | |||
---|---|---|---|
Placebo (n=58) | Tolcapone | ||
100 mg tid (n=60) | 200 mg tid (n=59) | ||
Dyskinesia3-150 | 12 (21) | 22 (37) | 31 (52.5) |
Nausea3-150 | 8 (14) | 16 (27) | 17 (29) |
Insomnia3-150 | 10 (17) | 15 (25) | 12 (20) |
Orthostatic complaints3-150 | 6 (10) | 16 (27) | 12 (20) |
Muscle cramps3-150 | 6 (10) | 13 (22) | 10 (17) |
Excessive dreaming3-150 | 8 (14) | 14 (23) | 5 (8.5) |
Diarrhoea | 2 (3) | 9 (15) | 15 (25) |
Somnolence3-150 | 5 (9) | 12 (20) | 7 (12) |
Vomiting3-150 | 2 (3) | 7 (12) | 5 (8.5) |
Headache | 2 (3) | 6 (10) | 2 (3) |
Akathisia/restlessness | 0 (0) | 3 (5) | 4 (7) |
Abdominal pain | 1 (2) | 1 (2) | 4 (7) |
Dyspnoea | 1 (2) | 0 (0) | 4 (7) |
Hypotension | 0 (0) | 2 (3) | 3 (5) |
↵3-150 Corresponding to levodopainduced symptom check list used by investigators during the study; tid = three times daily.