Cerebrospinal fluid measures in relapsing-remitting (RR) and secondary progressive (SP) patients
| Units | Median values | Reference values | RR v SP | ||||||
|---|---|---|---|---|---|---|---|---|---|
| RR (n=17) | SP (n=16) | D2 | P value | ||||||
| Transudation: | |||||||||
| Albumin CSF:PB | 4.3 | 5.0 | 1.8–7.0 | 0.39 | 0.09 | ||||
| Cellular immunology: | |||||||||
| Mononuclear cells | μl | 8 | 3 | 0–4 | 0.61 | 0.03 | |||
| CD4+ | % | 71 | 71 | 50–80 | 0.03 | 0.63 | |||
| CD8+ | % | 20 | 21 | 15–37 | 0.004 | 0.86 | |||
| CD4+/CD8+ | 3.4 | 3.4 | 1–4 | 0.001 | 0.96 | ||||
| B1+ | % | 3 | 3 | 0–5 | 0.06 | 0.50 | |||
| Humoral immunology: | |||||||||
| IgG | mg/l | 37 | 43 | 11–38 | 0.11 | 0.36 | |||
| IgG index | 0.83 | 0.74 | 0.36–0.60 | 0.09 | 0.79 | ||||
| IgM | mg/l | 0.6 | 0.4 | 0.1–0.4 | 0.36 | 0.10 | |||
| IgM index | 0.07 | 0.05 | 0.01–0.07 | 0.27 | 0.15 | ||||
| Complement C3 | mg/l | 2.0 | 2.2 | 0.9–6.7 | 0.41 | 0.08 | |||
| Complement C3 index | 0.57 | 0.60 | 0.32–0.77 | 0.004 | 0.86 | ||||
| Complement C4 | mg/l | 1.3 | 1.5 | 0.6–3.5 | 0.28 | 0.14 | |||
| Complement C4 index | 0.92 | 1.07 | 0.4–1.7 | 0.04 | 0.58 | ||||
| Demyelination: | |||||||||
| MBP | μg/l | 0.6 | 0.5 | 0.2–1.2 | 0.19 | 0.22 | |||
| Neuronal damage: | |||||||||
| NSE | μg/l | 6.2 | 4.9 | 2.0–10.0 | 0.30 | 0.12 | |||
| Glial damage: | |||||||||
| S100 | μg/l | 1.5 | 1.2 | 0.7–2.0 | 0.29 | 0.13 | |||
| Metabolic change: | |||||||||
| Lactate | μmol /l | 1660 | 1785 | 1380–1900 | 0.45 | 0.08 | |||
Median values, reference values, and statistical distance D2 are given for each variable. PB = peripheral blood; MBP = myelin basic protein; NSE = neuron specific enolase.