Table 1

Selected demographic and pathological features of controls (C), undemented cases with vascular disease (UDV) and cases with vascular dementia (DV)

C n (%)UDV n (%)DV n (%)
Number181924
Men (n(%))10  (55)12  (63)9  (38)
Women (n(%))8 (45)7 (37)15 (62)
Age (y (SD))80 (9)83 (9)76 (9)****
Brain WT (g (SD)):
 Men1307 (149)1337 (76)1284 (219)
 Women1184 (78)1127 (92)1125 (107)
Fixed cerebral hemisphere wt:
 Men599 (58)590 (39)540 (102)
 Women522 (37)517 (82)499 (29)
Circle of Willis atheroma:
 None724
 Any (score 1-3)10 171-150 20
 Severe (score 2/3)1  7** 8
Internal carotid atheroma:
 Present697
 Absent375
Myocardial pathology:
 Infarction3 (18)11 (58)*** 8 (40)
 Left ventricular hypertrophy7 (41)6 (32)8 (40)
AD pathology:
 No plaques or tangles7614
 A few plaques and/or tangles111310
  • 1-150 P=0.029; **P=0.042; ***P=0.019 v C by Fisher’s exact test; ****P=0.0008 v UDV by two tailed unpaired student t test, no significant difference from C.

  • AD = Alzheimer’s disease.