Asymptomatic MJD gene carriers | Control subjects (mean (SD)) (n=10) | |||||||
---|---|---|---|---|---|---|---|---|
Subject 1 | Subject 2 | Subject 3 | Subject 4 | Subject 5 | Subject 6 | Subject 7 | ||
Age (y) | 13 | 22 | 23 | 25 | 25 | 39 | 47 | 46.9 (11.8) |
CAG repeat number | 80 | 63 | 76 | 73 | 73 | 62 | 69 | 21.7 (7.0) |
CH/TH | 0.72 (82) | 0.77 (88) | 0.82 (93) | 0.79 (90) | 0.78 (89) | 0.81 (92) | 0.84 (95) | 0.88 (0.03) |
BS/TH | 0.73 (94) | 0.59 (76) | 0.76 (97) | 0.60 (77) | 0.65 (83) | 0.68 (81) | 0.77 (99) | 0.78 (0.08) |
O/TH | 0.84 (91) | 0.78 (85) | 0.86 (93) | 0.87 (95) | 0.78 (85) | 0.97 (105) | 0.95 (103) | 0.92 (0.04) |
P/TH | 1.0 (104) | 0.97 (101) | 1.20 (125) | 1.04 (108) | 1.08 (113) | 1.20 (125) | 1.05 (109) | 0.96 (0.03) |
T/TH | 0.95 (106) | 0.92 (102) | 1.11 (123) | 1.09 (121) | 1.00 (111) | 1.04 (116) | 1.02 (113) | 0.90 (0.04) |
Numbers in parentheses for the asymptomatic MJD gene carriers represent percentage of each ratio compared with the mean of control subjects.
CH = cerebellar hemisphere; BS = brainstem; O = occipital; P = parietal; T = temporal; TH = thalamus.